Regioselective Iodine/Zinc Exchange for the Selective Functionalization of Polyiodinated Arenes and Heterocycles in Toluene

Sanchez, Florian; Desaintjean, Alexandre; Danton, Fanny und Knochel, Paul (2021): Regioselective Iodine/Zinc Exchange for the Selective Functionalization of Polyiodinated Arenes and Heterocycles in Toluene. In: Synthesis-Stuttgart, Bd. 53, Nr. 24: S. 4662-4671

Abstract

Regioselective I/Zn-exchange reactions were performed on polyiodinated arenes or heterocycles within 20 minutes at 0-25 degrees C using the bimetallic combination p Tol (2) Zn center dot 2LiOR [R = (CH (2) ) (2) N(Me)(CH (2) ) (2) NMe (2) ] in toluene. The resulting diaryl- or diheteroarylzincs reacted well with allylic bromides and acyl chlorides to provide functionalized (hetero)aryl iodides in good yields.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch