Subthreshold laser therapy with a standardized macular treatment pattern in chronic central serous chorioretinopathy

Schworm, Benedikt; Siedlecki, Jakob; Keidel, Leonie F.; Herold, Tina R.; Luft, Nikolaus und Priglinger, Siegfried G. (2021): Subthreshold laser therapy with a standardized macular treatment pattern in chronic central serous chorioretinopathy. In: Graefes Archive for Clinical and Experimental Ophthalmology, Bd. 259, Nr. 11: S. 3271-3281

Abstract

Purpose There is an ongoing controversial debate about the effectiveness of laser treatments in chronic central serous chorioretinopathy (cCSC). We performed a prospective non-randomized interventional study to learn about the effects of a subthreshold laser treatment (Topcon Endpoint Management (TM), Topcon Healthcare Inc., Tokyo, Japan) in patients with cCSC. Methods Patients with cCSC and a minimum symptom duration of 4 months were included and treated with a standardized laser pattern covering the macular area. Retreatment was performed every 3 months if persistent subretinal fluid was observed. The primary endpoint was resolution of subretinal fluid at 6 months. Further outcome parameters included best corrected visual acuity, microperimetry, central macular and subfoveal choroidal thickness. Results A total of 42 eyes of 39 patients were included. Mean patient age was 48 +/- 10.6 years (range 25-67). Mean symptomatic time before inclusion into the study was 134 +/- 133.4 weeks (16-518). Before inclusion, 78.6% of the patients had failed to resolve subretinal fluid under mineralocorticoid receptor antagonists and 14.3% had a recurrence after half-dose photodynamic therapy. Complete resolution of subretinal fluid was observed in 42.9% at 6 months and in 53.8% at 12 months after baseline. Central retinal thickness decreased from 398 +/- 135 mu m to 291 +/- 68 mu m (p < 0.001), subfoveal choroidal thickness changed slightly (430 +/- 116 mu m to 419 +/- 113 mu m, p = 0.026), microperimetry-derived macular function improved by 19.1 +/- 4.7 dB to 21.3 +/- 4.8 dB (p = 0.008) and mean BCVA improved by 4.9 +/- 8.6 ETDRS letters (p < 0.001). Conclusion The results show that the investigated laser treatment is effective in reducing subretinal fluid and leads to an improvement of functional parameters.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0721-832X
• Sprache: Englisch