Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Serr, Isabelle; Drost, Felix; Schubert, Benjamin und Daniel, Carolin (22. Juli 2021): Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities. In: Frontiers in Immunology, Bd. 12, 712870

Abstract

Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity. The antigen-specific induction of Tregs is a long-envisioned goal for the treatment of autoimmune diseases given reduced side effects compared to general immunosuppressive therapies. However, the translation of antigen-specific Treg inducing therapies for the treatment or prevention of autoimmune diseases into the clinic remains challenging. In this mini review, we will discuss promising results for antigen-specific Treg therapies in allergy and specific challenges for such therapies in autoimmune diseases, with a focus on type 1 diabetes (T1D). We will furthermore discuss opportunities for antigen-specific Treg therapies in T1D, including combinatorial strategies and tissue-specific Treg targeting. Specifically, we will highlight recent advances in miRNA-targeting as a means to foster Tregs in autoimmunity. Additionally, we will discuss advances and perspectives of computational strategies for the detailed analysis of tissue-specific Tregs on the single-cell level.

• Dokumententyp: Zeitschriftenartikel
• Keywords: Antigen-specific Treg therapy; autoimmunity; T1D; microRNAs; tissue Tregs; single-cell multi-omics integration; TCR specificity prediction
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1664-3224
• Sprache: Englisch