Abstract
The novel tau-PET tracer [F-18]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [F-18]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [F-18]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [F-18]PI-2620-positive clusters (DVR >= 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1(SRTM): 0.92 +/- 0.21 vs. 0.83 +/- 0.10, p = 0.0007), higher efflux (k2(SRTM): 0.17/min +/- 0.21/min vs. 0.06/min +/- 0.07/min, p < 0.0001), lower DVR (1.1 +/- 0.1 vs. 1.4 +/- 0.2, p < 0.0001), lower SUVR30-60 (1.3 +/- 0.2 vs. 1.8 +/- 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope(9-60): 0.006/min +/- 0.007/min vs. 0.016/min +/- 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [F-18]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-102215-7 |
ISSN: | 0271-678X |
Language: | English |
Item ID: | 102215 |
Date Deposited: | 05. Jun 2023, 15:39 |
Last Modified: | 14. Jun 2024, 09:29 |