Polyethylene glycol-coated collagen patch (hemopatch(R)) in open partial nephrectomy

Staehler, Michael; Rodler, S.; Schott, M.; Casuscelli, J.; Stief, C.; Spek, A. und Schlenker, B. (2021): Polyethylene glycol-coated collagen patch (hemopatch(R)) in open partial nephrectomy. In: World Journal of Urology, Bd. 40, Nr. 1: S. 127-132

Abstract

Purpose To describe the results of a polyethylene glycol-coated collagen patch, Hemopatch(R) on blood loss, surgical time and renal function in partial nephrectomy (PN) for renal cell carcinoma (RCC). Methods Out of a single surgeon cohort of n = 565 patients undergoing conventional open PN (CPN) between 01/2015 and 12/2017 at the University of Munich a consecutive subgroup (n = 42) was operated on using a polyethylene glycol-coated collagen-based sealant Hemopatch(R) (Baxter International Inc., Deerfield, IL, USA) (HPN). Results Median age was 65.2 years (range 12.7-95.2) with median follow-up of 9.43 months (0.03-49.15). Baseline renal function (CKD-EPI) was 78.56 ml/min/1.73 m(2) (range 20.38-143.09) with a non-significant decline to 74.78 ml/min/1.73 m(2) (range 3.75-167.74) at follow-up. In CPN 46% had low complexity, 33% moderate complexity and 20% high complexity lesions with 33% low, 40% moderate and 27% high complexity masses in HPN. Median tumor size was 4.3 cm (range 1-38 cm) in CPN with 4.8 cm (range 3.8-18.3 cm) with HPN, p = 0.293. Median blood loss and duration of surgery was significantly lower in the HPN group vs. CPN (146 ml +/- 195 vs. 114 ml +/- 159 ml;p = 0.021;43 min +/- 27 for HPN vs. 53 min +/- 49;p = 0.035) with no difference in clamping time (12.6 min +/- 8.6 for HPN vs. 12.0 min +/- 9.5;p = 0.701). Conclusions Hemopatch(R) supported renoraphy shows promising results compared to standard renoraphy in PN. No side effects were seen. Further studies should evaluate the prevention of arterio-venous or urinary fistulas. In complex partial nephrectomies Hemopatch(R) supported renoraphy should be considered.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0724-4983
• Sprache: Englisch