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Triebelhorn, Julian; Haschka, Stefanie; Hesse, Felix; Erber, Johanna; Weidlich, Simon; Lee, Marcel; Hoffmann, Dieter; Eberle, Josef und Spinner, Christoph D. (2021): Acute HIV infection syndrome mimicking COVID-19 vaccination side effects: a case report. In: Aids Research and Therapy, Bd. 18, Nr. 1, 78

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Abstract

Background Symptoms of primary HIV infection, including fever, rash, and headache, are nonspecific and are often described as flu-like. COVID-19 vaccination side effects, such as fever, which occur in up to 10% of people following COVID-19 vaccination, can make the diagnosis of acute HIV infection even more challenging. Case presentation A 26-year-old man presented with fever and headache following COVID-19 vaccination. The symptoms were initially thought to be vaccine side effects. A diagnostic workup was conducted due to persisting fever and headache > 72 h following vaccination, and he was diagnosed with Fiebig stage II acute HIV infection, 3 weeks after having unprotected anal intercourse with another man. Conclusion Thorough anamnesis is key to estimating the individual risk of primary HIV infection, in patients presenting with flu-like symptoms. Early diagnosis and initiation of antiretroviral therapy is associated with better prognosis and limits transmission of the disease.

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