The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis

Upthegrove, Rachel; Lalousis, Paris; Mallikarjun, Pavan; Chisholm, Katharine; Griffiths, Sian Lowri; Iqbal, Mariam; Pelton, Mirabel; Reniers, Renate; Stainton, Alexandra; Rosen, Marlene; Ruef, Anne; Dwyer, Dominic B.; Surman, Marian; Haidl, Theresa; Penzel, Nora; Kambeitz-Llankovic, Lana; Bertolino, Alessandro; Brambilla, Paolo; Borgwardt, Stefan; Kambeitz, Joseph; Lencer, Rebekka; Pantelis, Christos; Ruhrmann, Stephan; Schultze-Lutter, Frauke; Salokangas, Raimo K. R.; Meisenzahl, Eva; Wood, Stephen J. und Koutsouleris, Nikolaos (2021): The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis. In: Schizophrenia Bulletin, Bd. 47, Nr. 1: S. 249-258

Abstract

Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP-D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP-D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders;however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0586-7614
• Sprache: Englisch