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Wu, Yang; Zhang, Chun; Jiang, Kuirong; Werner, Jens; Bazhin, Alexandr V. und D'Haese, Jan G. (14. Januar 2021): The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives. In: Frontiers in Oncology, Bd. 10, 621937 [PDF, 915kB]

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

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