The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Wu, Yang; Zhang, Chun; Jiang, Kuirong; Werner, Jens; Bazhin, Alexandr V. und D'Haese, Jan G. (14. January 2021): The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives. In: Frontiers in Oncology, Vol. 10, 621937

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

• Item Type: Journal article
• Keywords: Pancreatic stellate cells, pancreatic ductal adenocarcinoma, tumor microenvironment, stroma-targeting strategy, tumor therapy
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 2234-943X
• Language: English