Instrumental analysis of RNA modifications

Yoluc, Yasemin; Ammann, Gregor; Barraud, Pierre; Jora, Manasses; Limbach, Patrick A.; Motorin, Yuri; Marchand, Virginie; Tisne, Carine; Borland, Kayla and Kellner, Stefanie (2021): Instrumental analysis of RNA modifications. In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 56, No. 2: pp. 178-204

Abstract

Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks. Here, we will review recent advances and breakthroughs achieved by NMR spectroscopy, sequencing, and mass spectrometry of the epitranscriptome.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1040-9238
• Language: English