Roadmap for precision preclinical x-ray radiation studies

Verhaegen, Frank; Butterworth, Karl T.; Chalmers, Anthony J.; Coppes, Rob P.; de Ruysscher, Dirk; Dobiasch, Sophie; Fenwick, John D; Granton, Patrick V.; Heijmans, Stefan H. J.; Hill, Mark A.; Koumenis, Constantinos; Lauber, Kirsten ; Marples, Brian; Parodi, Katia ; Persoon, Lucas C. G. G; Staut, Nick; Subiel, Anna; Vaes, Rianne D. W.; van Hoof, Stefan; Verginadis, Ioannis L; Wilkens, Jan J.; Williams, Kaye J.; Wilson, George D. und Dubois, Ludwig J. (March 2023): Roadmap for precision preclinical x-ray radiation studies. In: Physics in Medicine & Biology, Vol. 68, No. 6, 06RM01

Abstract

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

• Item Type: Journal article
• EU Funded Grant Agreement Number: 725539
• EU Projects: Horizon 2020 > ERC Grants > ERC Consolidator Grant > ERC Grant 725539: SIRMIO - Small Animal Ion Irradiator for Research in Molecular Image-Guided Radio-Oncology
• Form of publication: Publisher's Version
• Keywords: preclinical; cancer models; precision; imaging; irradiation; translation; dosimetry
• Faculties: Physics
• Subjects: 500 Science > 530 Physics; 600 Technology > 610 Medicine and health
• Language: English