Primary aldosteronism: Pathophysiological mechanisms of cell death and proliferation

Tetti, Martina; Gong, Siyuan; Veglio, Franco; Reincke, Martin and Williams, Tracy Ann (8. August 2022): Primary aldosteronism: Pathophysiological mechanisms of cell death and proliferation. In: Frontiers in Endocrinology, Vol. 13

Abstract

Primary aldosteronism is the most common surgically curable form of hypertension. The sporadic forms of the disorder are usually caused by aldosterone overproduction from a unilateral adrenocortical aldosterone-producing adenoma or from bilateral adrenocortical hyperplasia. The main knowledge-advances in disease pathophysiology focus on pathogenic germline and somatic variants that drive the excess aldosterone production. Less clear are the molecular and cellular mechanisms that lead to an increased mass of the adrenal cortex. However, the combined application of transcriptomics, metabolomics, and epigenetics has achieved substantial insight into these processes and uncovered the evolving complexity of disrupted cell growth mechanisms in primary aldosteronism. In this review, we summarize and discuss recent progress in our understanding of mechanisms of cell death, and proliferation in the pathophysiology of primary aldosteronism.

• Item Type: Journal article
• Faculties: Medicine > Medical Center of the University of Munich
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1664-2392
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892