Abstract
Purpose To investigate the impact of treatment time and patterns in inoperable stage III non-small cell lung cancer (NSCLC) following concurrent chemoradiotherapy (cCRT) +/- immune checkpoint inhibitors (ICIs). Methods Patients were stratified by treatment year: A (2011-2014), B (2015-2017) and C (2018-2020). Tumor- and treatment-related characteristics regarding locoregional recurrence-free survival (LRRFS), progression-free survival (PFS) and overall survival (OS) were investigated. Results One hundred and thirty-six consecutive patients were analyzed. All patients completed thoracic radiotherapy (TRT) to a total dose >= 60.0 Gy;36 (26%) patients received ICI. Median PFS in subgroups A, B and C was 8.0, 8.2 and 26.3 months (p = 0.007). Median OS was 19.9 months, 23.4 months and not reached (NR), respectively. In group C, median LRRFS and PFS were 27.2 vs. NR;and 14.2 vs. 26.3 months in patients treated with and without ICI. On multivariate analysis planning target volume (PTV) >= 700 cc was a negative prognosticator of LRRFS (HR 2.194;p = 0.001), PFS (HR 1.522;p = 0.042) and OS (HR 2.883;p = 0.001);ICI was a predictor of LRRFS (HR 0.497;p = 0.062), PFS (HR 0.571;p = 0.071) and OS (HR 0.447;p = 0.1). In the non-ICI cohort, multivariate analyses revealed PTV >= 700 cc (p = 0.047) and a maximum standardized uptake value (SUVmax) >= 13.75 (p = 0.012) were predictors of PFS;PTV >= 700 cc (p = 0.017), SUVmax >= 13.75 (p = 0.002) and a total lung V20 >= 30% (V20 >= 30) (p < 0.05) were predictors of OS. Conclusions Patients treated after 2018 had improved survival regardless of ICI use. Implementation of ICI resulted in further significant increase of all tested survival endpoints. PTV >= 700 cc and ICI were only prognosticators for LRRFS, PFS and OS in the analyzed cohort.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
URN: | urn:nbn:de:bvb:19-epub-106395-2 |
ISSN: | 0171-5216 |
Sprache: | Englisch |
Dokumenten ID: | 106395 |
Datum der Veröffentlichung auf Open Access LMU: | 11. Sep. 2023, 13:38 |
Letzte Änderungen: | 20. Sep. 2023, 04:36 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892 |