High RIG-I and EFTUD2 expression predicts poor survival in endometrial cancer

Beyer, Susanne; Müller, Lena; Mitter, Sophie; Keilmann, Lucia; Meister, Sarah; Buschmann, Christina; Kraus, Fabian; Topalov, Nicole E.; Czogalla, Bastian; Trillsch, Fabian; Burges, Alexander; Mahner, Sven; Schmoeckel, Elisa; Löb, Sanja; Corradini, Stefanie; Kessler, Mirjana; Jeschke, Udo und Kolben, Thomas (2022): High RIG-I and EFTUD2 expression predicts poor survival in endometrial cancer. In: Journal of Cancer Research and Clinical Oncology

Abstract

Purpose Endometrial cancer is the most common gynecological malignancy. The helicase RIG-I, a part of the innate immune system, and EFTUD2, a splicing factor which can upregulate RIG-I expression, are shown to influence tumor growth and disease progression in several malignancies. For endometrial cancer, an immunogenic cancer, data about RIG-I and EFTUD2 are still missing. The aim of this study was to examine the expression of RIG-I and EFTUD2 in endometrial cancer. Methods 225 specimen of endometrial cancer were immunohistochemically stained for RIG-I and EFTUD2. The results were correlated to clinicopathological data, overall survival (OS) and progression-free survival (PFS). Results High RIG-I expression correlated with advanced tumor stages (FIGO: p = 0.027;pT: p = 0.010) and worse survival rates (OS: p = 0.009;PFS: p = 0.022). High EFTUD2 expression correlated to worse survival rates (OS: p = 0.026;PFS: p < 0.001) and was determined to be an independent marker for progression-free survival. Conclusion Our data suggest that the expression of RIG-I and EFTUD2 correlates with survival data, which makes both a possible therapeutic target in the future.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0171-5216
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892