Failed regeneration and inflammation in schizophrenia: two sides of the same coin?

Falkai, Peter und Schmitt, Andrea (2022): Failed regeneration and inflammation in schizophrenia: two sides of the same coin? In: Journal of Neural Transmission, Bd. 129, Nr. 5-6: S. 611-615

Abstract

More than 100 years after its conceptual definition as 'Dementia Praecox' by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. The neurodevelopmental hypothesis of schizophrenia, introduced more than 30 years ago, states that schizophrenia is a consequence of failed neurodevelopmental processes leading to a dysfunctional neuronal network forming the basis for a psychosis proneness. Subsequently, significant research efforts were made to prove the neurodevelopmental or the neurodegenerative perspective. This review summarizes key arguments speaking for or against the two hypotheses leading to a concept with both aspects position side by side.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0300-9564
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892