Frequency of translocation of USP-6 in the aneurysmal bone cyst of the jaw

Obermeier, Katharina Theresa; Schmoeckel, Elisa; Otto, Sven und Haidari, Selgai (2022): Frequency of translocation of USP-6 in the aneurysmal bone cyst of the jaw. In: Journal of Oral Pathology & Medicine, Vol. 52, No. 2: pp. 145-149

Abstract

Background: This study aims to detect USP6 translocation in aneurysmal cysts located in the jaw and to give an overview of demographic data. Methods: The present retrospective cohort study includes 10 patients who underwent surgery due to an aneurysmal cyst of the jaw in our hospital between 2002 and 2021. Unstained formalin-fixed and paraffin-embedded tissue sections cut at 4 mu m thickness were subjected to USP6 FISH testing. Results: All patients underwent surgical treatment. In four of ten patients (40%) USP-6-translocations have been found. Conclusion: Based on the study, it is hypothesized that the aneurysmal bone cyst of the jaw bone may be subject to a different pathomechanism than that of the long bones. Therefore, it seems conceivable that the primary cause of aneurysmal bone cysts in the jaw might differ.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0904-2512
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892