Iron-Catalyzed Radical Zincations of Alkyl Iodides

Sunagatullina, Alisa S.; Lutter, Ferdinand H.; Karaghiosoff, Konstantin und Knochel, Paul (2022): Iron-Catalyzed Radical Zincations of Alkyl Iodides. In: Advanced Synthesis & Catalysis, Bd. 364, Nr. 23: S. 4049-4053

Abstract

We report a new iron-catalyzed I/Zn-exchange allowing to convert primary or tailored secondary alkyl iodides into the corresponding alkylzinc iodides. In the presence of a remote double bond at position 5, diastereoselective ring closures are observed. Quenching of these zinc reagents, after transmetalation to copper species (with CuCN center dot 2LiCl) or under Pd-catalysis, with typical electrophiles (allyl bromides, acid chlorides or aryl iodides) gave various polyfunctional products.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1615-4150
• Sprache: Englisch
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892