Abstract
We report a convenient preparation of a new and storable magnesium amide (iPr(2)N)(2)Mg (magnesiumbis-diisopropylamide;MBDA) which proved to be especially suitable for the non-cryogenic magnesiation of fluoro-substituted arenes and heteroarenes providing arylmagnesium amides (ArMgDA) or bis-heteroaryl magnesiums (HetAr)(2)Mg in hydrocarbons. Further reactions with electrophiles (aldehydes, ketones, allylic bromides, aryl halides (Negishi cross-coupling)) furnished a range of polyfunctional fluoro-substituted unsaturated building blocks. Several postfunctionalizations were described as well as NMR-studies confirming the dimeric structure of the base.
Item Type: | Journal article |
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Faculties: | Chemistry and Pharmacy > Department of Chemistry |
Subjects: | 500 Science > 540 Chemistry |
URN: | urn:nbn:de:bvb:19-epub-106952-6 |
ISSN: | 1433-7851 |
Language: | English |
Item ID: | 106952 |
Date Deposited: | 11. Sep 2023, 13:45 |
Last Modified: | 05. Oct 2023, 17:08 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 491502892 |