Mantle cell lymphoma—Update on molecular biology, prognostication and treatment approaches

Silkenstedt, Elisabeth und Dreyling, Martin (2023): Mantle cell lymphoma—Update on molecular biology, prognostication and treatment approaches. In: Hematological Oncology, Vol. 41, No. S1: pp. 36-42

Abstract

Mantle cell lymphoma (MCL) is clinically characterized by its heterogenous behavior with courses ranging from indolent cases that do not require therapy for years to highly aggressive MCL with very limited prognosis. The development and implementation of new targeted and immunotherapeutic approaches have already improved therapeutic options especially for refractory or relapsed disease. Nevertheless, to further optimize MCL treatment, early identification of individual risk profile and risk-adapted, patient-tailored choice of therapeutic strategy needs to be prospectively incorporated in clinical patient management. This review summarizes the current knowledge and standard of care regarding biology and clinical management of MCL, highlighting the implementation of new therapeutic approaches especially targeting the immune system.

• Item Type: Journal article
• Faculties: Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic II (Gastroenterology, Hepatology)
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0278-0232
• Language: English