Cytotoxic Activity of Some Half‐sandwich Rhodium(III) Complexes Containing 4,4’‐disubstituted‐2,2’‐bipyridine Ligands

Graf, Marion; Ochs, Jasmine; Mayer, Peter; Metzler‐Nolte, Nils und Böttcher, Hans‐Christian (2024): Cytotoxic Activity of Some Half‐sandwich Rhodium(III) Complexes Containing 4,4’‐disubstituted‐2,2’‐bipyridine Ligands. In: Zeitschrift für anorganische und allgemeine Chemie, Bd. 650, Nr. 1

Abstract

The synthesis and characterization of three compounds [Rh(η5-C5Me5)Cl(N^N)]PF6 (N^N=4,4’-disubstituted-2,2’-bipyridines, 1–3) are described. The cationic complexes contain the bidentate ligands N^N=4,4'-di-tert-butyl-2,2'-bipyridine (1), N^N=4,4'-dinonyl-2,2'-bipyridine (2) and N^N=4,4'-diamino-2,2'-bipyridine (3). The complex salts were obtained by the bridge-splitting reaction from the precursor [{Rh(η5-C5Me5)(μ-Cl)Cl}2] and subsequent salt metathesis affording their corresponding hexafluorido phosphate salts. All compounds were characterized by elemental analysis and spectroscopic means. Additionally, the molecular structure of compound 3 in the solid was determined by a single-crystal X-ray diffraction study. The cytotoxicity of all three compounds was examined by MTT assay against two cancer cell lines – HT-29 (colon adenocarcinoma) and MCF-7 (human breast adenocarcinoma) - and normal human fibroblast cells (GM5657T). Compound 1 has moderate cytotoxicity against both cell lines, while compound 2 is seven to nine times more cytotoxic than cisplatin against MCF-7 and HT-29, respectively. In contrast to cisplatin, both compounds are more active against cancer cells than fibroblasts, thus showing some cancer selectivity.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0044-2313
• Sprache: Englisch