Cross‐reactive carbohydrate determinants in atopic and healthy dogs and their influence on allergy test specificity

Kasper, Bettina ; Boehm, Teresa; Wittenstein, Nadine und Mueller, Ralf S. (2023): Cross‐reactive carbohydrate determinants in atopic and healthy dogs and their influence on allergy test specificity. In: Veterinary Record, Bd. 193, Nr. 10

Abstract

Background The selection of allergens for immunotherapy in atopic dogs is often based on serum allergy testing. Cross-reactive carbohydrate determinants (CCDs) are common structures in plant and insect allergens that reportedly induce polysensitisation, reduce agreement between intradermal and serum tests and complicate allergen selection.

Methods Thirty-four dogs with diagnosed atopic dermatitis and 10 healthy dogs were included in the study. An intradermal test was conducted in atopic dogs, and serum samples from allergic and healthy dogs were analysed for allergen-specific immunoglobulin E (IgE) before and after inhibition of detectable anti-CCD-IgE antibodies.

Results Anti-CCD-IgE antibodies were not found in any of the healthy dogs and no polysensitisation to plant and insect allergens was detected. The agreement between intradermal and serum allergy test results in the atopic dogs with anti-CCD-IgE antibodies improved from slight to fair after blocking the anti-CCD-IgE antibodies. In addition, blocking clearly reduced polysensitisation to plant allergens but not to acarid allergens.

Limitations Only a limited number of healthy dogs were tested in this study. A gold standard for determining the clinical relevance of IgE sensitisation does not exist.

Conclusion Inhibition of anti-CCD-IgE antibodies seems to be of importance to improve serum test specificity for allergen-specific IgE in atopic dogs in relation to intradermal allergy testing.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin > Zentrum für Klinische Tiermedizin > Medizinische Kleintierklinik
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0042-4900
• Sprache: Englisch