Globoid cell leukodystrophy in two dachshund siblings

Pausova, Tereza Kosinova; Rosati, Marco und Tomek, Ales (2022): Globoid cell leukodystrophy in two dachshund siblings. In: Veterinary Record Case Reports, Bd. 10, Nr. 2, e289

Abstract

An 11-week-old male dachshund and his 13-week-old female sibling presented with slowly progressive gait abnormalities, cerebellar ataxia and intention head tremor. In the pedigree of their parents, there were no signs of these neurological abnormalities. The MRI scan results, cerebrospinal fluid (CSF) and complete blood analysis obtained in the male dog were not consistent with metabolic, infectious or anomalous conditions, leaving a degenerative disorder as the most likely differential diagnosis. Both puppies were euthanased (male after 3 weeks and female after 6 weeks later) due to diffuse central nervous system abnormalities. Histopathology findings were consistent with globoid cell leukodystrophy. To the authors' knowledge, this is the first confirmed case of this lysosomal storage disease in a dachshund.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin > Veterinärwissenschaftliches Department
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch