Epigenomic Modifications in Modern and Ancient Genomes

Niiranen, Laura; Leciej, Dawid; Edlund, Hanna; Bernhardsson, Carolina; Fraser, Magdalena; Sanchez Quinto, Federico; Herzig, Karl-Heinz; Jakobsson, Mattias; Walkowiak, Jaroslaw und Thalmann, Olaf (2022): Epigenomic Modifications in Modern and Ancient Genomes. In: Genes, Bd. 13, Nr. 2, 178

Abstract

Epigenetic changes have been identified as amajor driver of fundamentalmetabolic pathways. More specifically, the importance of epigenetic regulatory mechanisms for biological processes like speciation and embryogenesis has beenwell documented and revealed the direct link between epigenetic modifications and various diseases. In this review, we focus on epigenetic changes in animals with special attention on human DNA methylation utilizing ancient and modern genomes. Acknowledging the latest developments in ancient DNA research, we further discuss paleoepigenomic approaches as the only means to infer epigenetic changes in the past. Investigating genome-wide methylation patterns of ancient humans may ultimately yield in a more comprehensive understanding of how our ancestors have adapted to the changing environment, and modified their lifestyles accordingly. We discuss the difficulties of working with ancient DNA in particular utilizing paleoepigenomic approaches, and assess new paleoepigenomic data, which might be helpful in future studies.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin > Veterinärwissenschaftliches Department
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch