Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons

Hess, Andreas; Alandini, Nurtalya; Guelen, Hasret C.; Prohaska, Jan P. und Knochel, Paul (2022): Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons. In: Chemical Communications, Vol. 58, No. 63: pp. 8774-8777

Abstract

We report the preparation of a new hydrocarbon-soluble magnesium amide TMP2Mg (TMP = 2,2,6,6-tetramethylpiperidyl). This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing ethyl esters and carbamates under very mild reaction conditions. Subsequent trapping with aryl iodides (Negishi cross-coupling) gave access to a range of highly functionalized valuable building blocks.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English