Synthesis, X-ray structure and anticancer activity evaluation of a binuclear La(III) complex with anthranilic acid

Zidan, Amna S. A.; Mosbah, Hanan K.; Aly, Aref A. M.; Ibrahim, Ahmed B. M.; Mayer, Peter und Saber, Saber H. (2022): Synthesis, X-ray structure and anticancer activity evaluation of a binuclear La(III) complex with anthranilic acid. In: Natural Product Research

Abstract

A binuclear La(III) complex {[La-2(HA)(4)(H2O)(4)(C2H5OH)(2)Cl-2]Cl-4 (C1)} with 2-aminobenzoic acid (HA) was prepared from the ligand and heptahydrated lanthanum chloride. The complex was characterised by X-ray crystallography that revealed anti-prismatic geometry around both of the lanthanum. In the complex, the four 2-aminobenzoic acid ligands are zwitter ionic and the two lanthanum(III) ions net charge is only counterbalanced by chloride ions. The complex cytotoxicity was determined against human breast (MDA-MB-231), prostate (PC-3) and bladder (T-24) cancer cells. This complex afforded cytotoxicity towards the T-24 bladder cancer cells with an IC50 value of 383.5 mu g/mL (319 mu M). In contrary, activities by the lanthanum complex with IC50 values of 1124 mu g/mL (934 mu M) and 739 mu g/mL (614 mu M) were, respectively, shown against the MDA-MB-231 and PC-3 cancer cells. This means the complex is more cytotoxic against the T-24 cells, despite that its activity is less compared with activities shown by classical drugs.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1478-6419
• Sprache: Englisch