Strain-release arylations for the bis-functionalization of azetidines

Trauner, Florian; Reiners, Felix; Apaloo-Messan, Kodjo-Edmond; Nissl, Benedikt; Shahbaz, Muhammad; Jiang, Dongfang; Aicher, Julian und Didier, Dorian (2022): Strain-release arylations for the bis-functionalization of azetidines. In: Chemical Communications, Bd. 58, Nr. 15: S. 2564-2567

Abstract

The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1359-7345
• Sprache: Englisch