Strain-release arylations for the bis-functionalization of azetidines

Trauner, Florian; Reiners, Felix; Apaloo-Messan, Kodjo-Edmond; Nissl, Benedikt; Shahbaz, Muhammad; Jiang, Dongfang; Aicher, Julian und Didier, Dorian (2022): Strain-release arylations for the bis-functionalization of azetidines. In: Chemical Communications, Vol. 58, No. 15: pp. 2564-2567

Abstract

The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English