Modular Synthesis of New Pyrroloquinoline Quinone Derivatives

Janssen, Rachel; Vetsova, Violeta A.; Putz, Dominik; Mayer, Peter and Daumann, Lena J. J. (2022): Modular Synthesis of New Pyrroloquinoline Quinone Derivatives. In: Synthesis, Vol. 55, No. 6: pp. 1000-1006

Abstract

Pyrroloquinoline quinone (PQQ) is an important cofactor of methanol dehydrogenases and glycose dehydrogenases. In addition, isolated PQQ is used as a central component in sensors and biomimetic complexes. The synthesis of PQQ derivatives is of interest for developing new alcohol oxidation catalysts and redox sensors. This work describes a modular synthesis for derivatives of PQQ bearing methyl and ketone groups instead of carboxylic acid moieties. These modifications reduce the possible coordination sites of PQQ for metal ions outside the protein environment.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0039-7881
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 392552271