Interpretation von systematischen Übersichtsarbeiten und Metaanalysen. Klinische Studien in Unfallchirurgie und Orthopädie

Stengel, Dirk; Mutschler, Wolf; Dubs, Luzi; Kirschner, Stephan and Renkawitz, Tobias (2022): Interpretation von systematischen Übersichtsarbeiten und Metaanalysen. Klinische Studien in Unfallchirurgie und Orthopädie. In: Unfallchirurgie, Vol. 125, No. 11: pp. 897-908

Abstract

Clinical trials must be planned and interpreted in the context of current best clinical and scientific evidence, undoubtedly provided by systematic reviews and meta-analyses, especially Cochrane Reviews. While many clinicians feel overwhelmed by this complex data source, few visual Elements (e.g., the traffic light system of the Cochrane risk of bias [RoB-2] tool, forest plots, etc.), together with indices such as the I-2 heterogeneity statistic, allow for a quick appraisal of all critical and necessary qualitative and quantitative information. The effectiveness of different treatment options can indirectly be assessed by methodological advancements like network meta-analyses. Point estimates of percentages are insufficient to describe the utility and value of a proposed novel intervention, which, in orthopedic and trauma surgery, often represents a step innovation. 95% confidence intervals and the so-called fragility index are helpful in determining the ultimate patient benefit.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 2731-7021
• Language: German