Logo Logo
Hilfe
Hilfe
Switch Language to English

Pakeerathan, T.; Havla, J.; Schwake, C.; Salmen, A.; Bigi, S.; Abegg, M.; Bruegger, D.; Ferrazzini, T.; Runge, A.-K.; Breu, M.; Kornek, B.; Bsteh, G.; Felipe-Rucian, A.; Ringelstein, M.; Aktas, O.; Karenfort, M.; Wendel, E.; Kleiter, I.; Hellwig, K.; Kuempfel, T.; Thiels, C.; Luecke, T.; Gold, R.; Rostasy, K. und Ayzenberg, I (2022): Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode. In: Journal of Neurology, Bd. 269, Nr. 12: S. 6366-6376

Volltext auf 'Open Access LMU' nicht verfügbar.

Abstract

Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MSped) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD(ped)) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode. Methods Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls. Results Thirteen MOGAD(ped) (10.7 +/- 4.2 years, F:M 8:5, 21 ON eyes) and 21 MSped (14.3 +/- 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGAD(ped) compared to MSped (pRNFL global: 68.2 +/- 16.9 vs. 89.4 +/- 12.3 mu m, p < 0.001;mRNFL: 0.12 +/- 0.01 vs. 0.14 +/- 0.01 mm(3), p < 0.001). Neither other macular layers nor P100 latency differed. MOGAD(ped) developed global atrophy affecting all peripapillary segments, while MSped displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff < 62.5 mu m, 90.5% sensitivity and 70.8% specificity for MOGAD(ped)). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%, p = 0.016). Conclusion First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.

Dokument bearbeiten Dokument bearbeiten