Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study

Stockdale, Lisa; Sambou, Basil; Sissoko, Muhamed; Egere, Uzochukwu; Sillah, Abdou K.; Kampmann, Beate und Basu Roy, Robin (2022): Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study. In: European Journal of Pediatrics, Bd. 181, Nr. 3: S. 1263-1267

Abstract

Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected;10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case. What is Known: center dot Paediatrics TB represents one of the leading causes of child death globally. center dot Current literature shows an inconsistent relationship between vitamin D deficiency and increased risk of TB disease however a large Phase 3 trial of vitamin D supplementation in (largely vitamin D deficient) Mongolian children did not find any association with TB infection rates. What is New: center dot This study adds to the literature in a vitamin D sufficient paediatric population whereby children with equal exposure to a household TB case with no evidence of TB infection have higher levels of vitamin D compared with matched children with TB infection.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-6199
• Sprache: Englisch