Behandlung von Sehnenrupturen mit Stammzellen: eine aktuelle Übersicht

Schmitz, Christoph; Wuerfel, Tobias; Alt, Christopher und Alt, Eckhard U. (2022): Behandlung von Sehnenrupturen mit Stammzellen: eine aktuelle Übersicht. In: Obere Extremität: Schulter, Ellenbogen, Bd. 17, Nr. 3: S. 141-153

Abstract

Background Orthobiologics are becoming increasingly more important both in basic research and in clinical research for conservative management and for improving the results of surgical treatment for diseases and injuries of the shoulder and elbow. Objective The importance of orthobiologics in the conservative management and in improving the results of surgical treatment of diseases and injuries of the shoulder and elbow;graded differentiation of the various tissue preparation methods within the orthobiologics in these forms of treatment. Material and methods Evaluation of meta-analyses;discussion of fundamental works and clinical studies. Results Orthobiologics can be functionally subdivided into two groups. Cell-free orthobiologics and those based on allogeneic cells must be functionally discussed (i.e. in relation to the mechanisms of action) together and the mechanisms of actions must be compared with those of orthobiologics based on autologous cells. According to the current literature, only the latter group seems to be suitable for conservative management and for improvement of the outcome of surgical treatment of rotator cuff diseases and injuries. Within this group, the adipose-derived regenerative cells (autologous ADRCs), that are neither selected and amplified in cell culture nor modified or stimulated, appear to be superior to all other tissue preparations in terms of effectiveness. Conclusion Autologous ADRCs represent a highly interesting new treatment option for diseases and injuries of the rotator cuff.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1862-6599
• Sprache: Deutsch