Engulf and digest-TRPM7 as key regulator of macrophage phagosome maturation

Hoeger, Birgit und Zierler, Susanna (2022): Engulf and digest-TRPM7 as key regulator of macrophage phagosome maturation. In: Cell Calcium, Bd. 106, 102636

Abstract

Localized intracellular calcium fluxes are indispensable for immunologically directed Fc receptor-mediated cellular phagocytosis. A similar dependency on calcium signals has been speculated to occur in efferocytosis, the clearance of non-opsonized apoptotic cell bodies by macrophages. In a recent study published in Nature Communications, Schappe et al. describe the TRPM7 ion channel as mediator of peri-phagosomal calcium currents, ensuring maturation of the acidifying phagosome. The authors identified a fundamental calcium signaling module provided by TRPM7, which is necessary for clearance of apoptotic cells. This finding updates our current molecular understanding of calcium dynamics, tissue maintenance and immunological clean-up.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0143-4160
• Sprache: Englisch