Logo Logo
Hilfe
Hilfe
Switch Language to English

Bueren, Moritz von; Rodler, Severin; Wiesenhuetter, Isabell; Schroeder, Florian; Buchner, Alexander; Stief, Christian; Gratzke, Christian; Wuelfing, Christian und Bueren, Johannes von (2022): Digital Real-world Data Suggest Patient Preference for Tadalafil over Sildenafil in Patients with Erectile Dysfunction. In: European Urology Focus, Bd. 8, Nr. 3: S. 794-802

Volltext auf 'Open Access LMU' nicht verfügbar.

Abstract

Background: Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase-5 inhibitors (PDE5is) used to treat ED. Objective: This study aimed to evaluate patient data of a large online prescription platform (OPP), specifically analyzing preference for tadalafil over sildenafil. Design, setting, and participants: Data from a prospectively collected German OPP were retrospectively analyzed. This dataset included patients with a history of taking one or both substances (n = 26 821).Outcome measurements and statistical analysis: ED patient baseline characteristics were derived from medical questionnaires for PDE5i prescriptions between May 2019 and May 2020. Order behavior was analyzed in patients who ordered both substances over time. We applied Kruskal-Wallis tests, x2 tests, and fisher's exact tests for statistical analysis. Results and limitations: Baseline characteristics were comparable for both PDE5is in patients with a median age of 49 yr (sildenafil [interquartile range {IQR} 38-57];tadalafil [IQR 39-56]), a median body mass index (BMI) of 26 kg/m2 (sildenafil [IQR 24.54-29.03];tadalafil [IQR 24.49-28.69]), ED onset time of > 12 mo (sildenafil [87%];tadalafil [88%]), and the presence of morning erections (sildenafil [62%];tadalafil [61%]). Tadalafil prescriptions increased significantly from 30% (first order) to 80% (last order) in patients who had already tested both drugs. Patients with age < 40 yr, BMI < 25 kg/m2, and sustained morning erections preferred tadalafil to sildenafil. Conclusions: Using database information from an OPP, preference for tadalafil was shown for patients who had tested both PDE5is. This preference was particularly pronounced in patients with age < 40 yr, BMI < 25 kg/m2, and sustained morning erections. A well -managed OPP can be used for research on more complex health services. Patient summary: Analysis of large online prescription platforms provide the benefit of identifying young treatment-naive patients with early-stage disease, which is highlighted by the fact that about two-thirds of our patients analyzed still maintained spontaneous morning erections. Patients who had tested tadalafil once developed preference for this drug. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.

Dokument bearbeiten Dokument bearbeiten