Mitral Valve Transcatheter Edge-to-Edge Repair Using MitraClip or PASCAL A Multicenter Propensity Score-Matched Comparison

Schneider, Leonhard; Markovic, Sinisa; Mueller, Katharina; Felbel, Dominik; Gercek, Muhammed; Friedrichs, Kai; Stolz, Lukas; Rudolph, Volker; Hausleiter, Jörg; Rottbauer, Wolfgang und Kessler, Mirjam (2022): Mitral Valve Transcatheter Edge-to-Edge Repair Using MitraClip or PASCAL A Multicenter Propensity Score-Matched Comparison. In: JACC Cardiovascular Interventions, Bd. 15, Nr. 24: S. 2554-2567

Abstract

BACKGROUND Since its introduction in 2003, Abbott's MitraClip (MC) has become the most established catheterbased treatment for mitral regurgitation (MR). Recent approval of Edwards Lifescience's PASCAL device has extended the field of TEER. OBJECTIVES The aim of this retrospective multicenter study was to compare the PASCAL and MC regarding procedural results and short- and long-term outcomes after mitral valve transcatheter edge-to-edge repair (TEER). METHODS Data from 3 high-volume centers were analyzed. The primary endpoint was residual MR at discharge. Secondary endpoints were technical success, MR reduction, and 30-day mortality. After 1 year, all-cause mortality and residual MR were reported. RESULTS A total of 412 patients (216 MC, 196 PASCAL) treated between 2018 and 2020 were included. A total of 184 patients (92 in each treatment group) remained after propensity score matching. The rate of baseline MR $3 was 98.9% in both groups (P = 1.00). Both TEER systems achieved equally high technical success rates (97.8%;P = 1.00), resulting in residual MR #1 in 69.6% vs 77.1% of patients (P = 0.24) and MR reduction by $2 grades in 83.7% vs 92.4% of patients (P = 0.13) using the MC and PASCAL, respectively. Thirty-day mortality was 1.1% in both cohorts (P = 0.98), and 1-year follow-up showed similar MR reductions (residual MR #1, 78.0% with MC vs 82.3% with PASCAL;P = 0.70) and comparable all-cause mortality (14.1% with MC vs 6.5% with PASCAL;P = 0.14). In multivariate regression analysis, Society of Thoracic Surgeons score independently correlated with an optimal result (MR #1), while device choice did not show a significant impact. CONCLUSIONS In this retrospective multicenter study, the established MC and the novel PASCAL mitral valve TEER systems were safe and offered excellent performance with comparable short- and long-term outcomes. (J Am Coll Cardiol Intv 2022;15:2554-2567) (c) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1936-8798
• Sprache: Englisch