Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses

Monteleone, Alessio Maria; Pellegrino, Francesca; Croatto, Giovanni; Carfagno, Marco; Hilbert, Anja; Treasure, Janet; Wade, Tracey; Bulik, Cynthia M.; Zipfel, Stephan; Hay, Phillipa; Schmidt, Ulrike; Castellini, Giovanni; Favaro, Angela; Fernandez-Aranda, Fernando; Il Shin, Jae; Voderholzer, Ulrich; Ricca, Valdo; Moretti, Davide; Busatta, Daniele; Abbate-Daga, Giovanni; Ciullini, Filippo; Cascino, Giammarco; Monaco, Francesco; Correll, Christoph U. and Solmi, Marco (2022): Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses. In: Neuroscience and Biobehavioral Reviews, Vol. 142, 104857

Abstract

MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX, 2022.-Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We sum-marized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standard-ized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. In-terventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control;also, antidepressants out-performed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0149-7634
• Language: English