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Monteleone, Alessio Maria; Pellegrino, Francesca; Croatto, Giovanni; Carfagno, Marco; Hilbert, Anja; Treasure, Janet; Wade, Tracey; Bulik, Cynthia M.; Zipfel, Stephan; Hay, Phillipa; Schmidt, Ulrike; Castellini, Giovanni; Favaro, Angela; Fernandez-Aranda, Fernando; Il Shin, Jae; Voderholzer, Ulrich; Ricca, Valdo; Moretti, Davide; Busatta, Daniele; Abbate-Daga, Giovanni; Ciullini, Filippo; Cascino, Giammarco; Monaco, Francesco; Correll, Christoph U. and Solmi, Marco (2022): Treatment of eating disorders: A systematic meta-review of meta-analyses and network meta-analyses. In: Neuroscience and Biobehavioral Reviews, Vol. 142, 104857

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MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX, 2022.-Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We sum-marized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standard-ized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. In-terventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control;also, antidepressants out-performed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).

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