The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control

Korn, Stephanie; Milger, Katrin; Skowasch, Dirk; Timmermann, Hartmut; Taube, Christian; Idzko, Marco; Voss, Hans Werner; Holtdirk, Annette; Hamelmann, Eckard und Buhl, Roland (2022): The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control. In: Respiratory Medicine, Bd. 195, 106793

Abstract

Introduction. The German Asthma Net Severe Asthma Registry is collecting long-term data from a large cohort of patients aged >= 6 years with severe asthma. This manuscript presents their baseline characteristics, and identifies relationships with exacerbations and/or poor asthma control. Methods. The registry is collecting routine clinical parameters including: demographics and medical history;disease characteristics (Asthma Control Questionnaire [ACQ]-5, forced expiratory volume in 1 s [FEV1]);exacerbations;and biomarkers (eosinophils, immunoglobulin E [IgE], fractional exhaled nitric oxide [FeNO]). Results. These analyses include data from 2011 patients at 72 sites (91.9% adult). Children (6-17 years) were more likely to be male, whereas more adults were female (males: children/adults 62%/41%). Most were receiving inhaled corticosteroid/long-acting beta(2)-agonist combinations (78%/81%);38.0% of adults were receiving systemic steroids. Asthma control was suboptimal in both groups: 21.5%/13.3% were controlled;10.4%/49.1% were symptomatic;33.1%/37.2% received emergency asthma treatment in the previous year. Median blood eosinophil (400/238 cells/mu L) and IgE levels (494/186 IU/mL) were higher in children;FeNO was lower (19/35 ppb). Patients with >= 2 exacerbations in the previous year had lower FEV1 (absolute and % predicted) and IgE, and higher ACQ-5, FeNO and blood eosinophil levels (all p < 0.05). There was a weak, negative correlation between ACQ-5 and FEV1% predicted in adults (p < 0.001). Conclusions. These analyses characterise the typical German patient with severe asthma, and provide information on their overall care. Their planned long-term follow-up will assess whether asthma control can be optimised, how best to do so, and most importantly how such optimisation can benefit patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0954-6111
• Sprache: Englisch