Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC-Is it the exception to the rule?

Kamphues, Carsten; Lefevre, Jeremie H.; Wang, Jane; Amini, Neda; Beaugerie, Laurent; Kühn, Florian; Park, Sang Hyoung; Andreatos, Nikolaos; Lauscher, Johannes C.; Enea, Diana; Lehmann, Kai S.; Peru, Nicolas; Weixler, Benjamin; Kirchgesner, Julien; Degro, Claudius E.; Pozios, Ioannis; Beekum, Cornelius J. van; Schoelch, Sebastian; Zambonin, Daniela; Schineis, Christian; Loch, Florian N.; Geka, Despoina; Theoxari, Maria; Wu, Bin; Wang, Pei-Pei; Antoniou, Efstathios; Pikoulis, Emmanouil; Moussata, Driffa; Theodoropoulos, George; Ouaissi, Mehdi; Seeliger, Hendrik; Inaba, Yosuke; Scaringi, Stefano; Reissfelder, Christoph; Vilz, Tim O.; Lin, Chen; Yang, Suk-Kyun; Beyer, Katharina; Renz, Bernhard W.; Sasaki, Kazunari; Margonis, Georgios Antonios; Svrcek, Magali und Kreis, Martin E. (2022): Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC-Is it the exception to the rule? In: Surgical Oncology, Bd. 45, 101874

Abstract

Background: Although primary tumor sidedness (PTS) has a known prognostic role in sporadic colorectal cancer (CRC), its role in Inflammatory Bowel Disease related CRC (IBD-CRC) is largely unknown. Thus, we aimed to evaluate the prognostic role of PTS in patients with IBD-CRC.Methods: All eligible patients with surgically treated, non-metastatic IBD-CRC were retrospectively identified from institutional databases at ten European and Asian academic centers. Long term endpoints included recur-rence-free (RFS) and overall survival (OS). Multivariable Cox proportional hazard regression as well as pro-pensity score analyses were performed to evaluate whether PTS was significantly associated with RFS and OS.Results: A total of 213 patients were included in the analysis, of which 32.4% had right-sided (RS) tumors and 67.6% had left-sided (LS) tumors. PTS was not associated with OS and RFS even on univariable analysis (5-year OS for RS vs LS tumors was 68.0% vs 77.3%, respectively, p = 0.31;5-year RFS for RS vs LS tumors was 62.8% vs 65.4%, respectively, p = 0.51). Similarly, PTS was not associated with OS and RFS on propensity score matched analysis (5-year OS for RS vs LS tumors was 82.9% vs 91.3%, p = 0.79;5-year RFS for RS vs LS tumors was 85.1% vs 81.5%, p = 0.69). These results were maintained when OS and RFS were calculated in patients with RS vs LS tumors after excluding patients with rectal tumors (5-year OS for RS vs LS tumors was 68.0% vs 77.2%, respectively, p = 0.38;5-year RFS for RS vs LS tumors was 62.8% vs 59.2%, respectively, p = 0.98). Conclusions: In contrast to sporadic CRC, PTS does not appear to have a prognostic role in IBD-CRC.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0960-7404
• Sprache: Englisch