Clinical outcomes of cancer-associated isolated superficial vein thrombosis in daily practice

Langer, Florian; Gerlach, Horst E.; Schimke, Alexandra; Heinken, Andreas; Hoffmann, Ulrich; Noppeney, Thomas; Pittrow, David; Klotsche, Jens; Rabe, Eberhard und Bauersachs, Rupert (2022): Clinical outcomes of cancer-associated isolated superficial vein thrombosis in daily practice. In: Thrombosis Research, Bd. 220: S. 145-152

Abstract

Background: Despite significant progress in the understanding of paraneoplastic deep vein thrombosis (DVT) and pulmonary embolism (PE), little is known about the outcomes of cancer-associated superficial vein thrombosis (SVT) in daily practice.Methods: INSIGHTS-SVT was a prospective observational study on patients with acute isolated SVT. Primary outcome measure was symptomatic venous thromboembolism (VTE), a composite of DVT, PE, and SVT exten-sion/recurrence, at 3 months. Clinically relevant bleeding was also assessed.Results: Of 1151 patients included, 6.7 % either had active cancer at baseline or were diagnosed with cancer during 12 months of follow-up. At 3 months, symptomatic VTE had occurred in 13.0 % and 5.4 % of cancer and non-cancer patients, respectively (HR 2.6, 95 % CI 1.3-5.0). Regarding secondary outcomes, cancer patients had increased risks of DVT and PE (HR 3.9, 95 % CI 1.3-11.8) and hospitalization due to VTE (HR 11.0, 95 % CI 2.5-49.0). The rate of clinically relevant bleeding was numerically higher in the cancer cohort (3.9 % vs 1.3 %, HR 3.1, 95 % CI 0.9-10.7). At 12 months, the primary composite outcome had occurred in 15.6 % and 11.9 % of cancer and non-cancer patients, respectively (HR 1.9, 95 % CI 1.0-3.5). After adjusting for additional risk factors, including age, history of DVT/PE and cardiovascular risk factors/diseases, the association of cancer with the primary outcome remained statistically significant.Conclusion: Cancer patients with isolated SVT are at significant risk of symptomatic VTE. While most events occur within 3 months, the VTE risk remains elevated up to one year of follow-up. ClinicalTrials.gov identifier: NCT02699151.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0049-3848
• Sprache: Englisch