Control of lymph node activity by direct local innervation

De Virgiliis, Francesco; Oliva, Valeria Maria; Kizil, Burak und Scheiermann, Christoph (2022): Control of lymph node activity by direct local innervation. In: Trends in Neurosciences, Bd. 45, Nr. 9: S. 704-712

Abstract

The nervous system detects environmental and internal stimuli and relays this in-formation to immune cells via neurotransmitters and neuropeptides. This is es-sential to respond appropriately to immunogenic threats and to support system homeostasis. Lymph nodes (LNs) act as sentinels where adaptive immune re-sponses are generated. They are richly innervated by peripheral sympathetic and sensory nerves, which are responsible for the local secretion of neurotrans-mitters by sympathetic fibers, such as norepinephrine, and neuropeptides by sensory fibers, including calcitonin gene-related peptide (CGRP) and substance P. Additionally, time-of-day-dependent oscillations in nerve activity are associ-ated with differential immune responses, suggesting a potential role for neuroimmune interactions in coordinating immunity in a circadian fashion. Here, we discuss how LN activity is controlled by local innervation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0166-2236
• Sprache: Englisch