The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2-Results from a prospective cohort of outpatient COVID-19 cases

Puchinger, Kerstin; Castelletti, Noemi; Rubio-Acero, Raquel; Geldmacher, Christof; Eser, Tabea M.; Deak, Flora; Paunovic, Ivana; Bakuli, Abhishek; Saathoff, Elmar; Meyer, Alexander von; Markgraf, Alisa; Falk, Philine; Reich, Jakob; Riess, Friedrich; Girl, Philipp; Mueller, Katharina; Radon, Katja ; Noller, Jessica Michelle Guggenbühl; Wölfel, Roman; Hölscher, Michael; Kroidl, Inge; Wieser, Andreas und Olbrich, Laura (2022): The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2-Results from a prospective cohort of outpatient COVID-19 cases. In: Virology, Bd. 569: S. 37-43

Abstract

Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days;p = 0.0016) and high viral loads (VL;median maximum VL: 3 center dot 10(8)( )copies/mL;p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin ; Medizin > Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0042-6822
• Sprache: Englisch