ORCID: https://orcid.org/0000-0002-5271-3972; Noller, Jessica Michelle Guggenbühl; Wölfel, Roman; Hölscher, Michael; Kroidl, Inge; Wieser, Andreas and Olbrich, Laura
(2022):
The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2-Results from a prospective cohort of outpatient COVID-19 cases.
In: Virology, Vol. 569: pp. 37-43
Abstract
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days;p = 0.0016) and high viral loads (VL;median maximum VL: 3 center dot 10(8)( )copies/mL;p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine Medicine > Institute and Polyclinic for Occupational, Social and Environmental Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 0042-6822 |
| Language: | English |
| Item ID: | 112472 |
| Date Deposited: | 02. Apr 2024, 07:36 |
| Last Modified: | 25. Apr 2024, 13:08 |
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