Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project

Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; Hoogh, Kees de; Taj, Tahir; Poulsen, Aslak Harbo; Andersen, Zorana J.; Bellander, Tom; Brandt, Jorgen; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Verschuren, W. M. Monique; Jorgensen, Jeanette T.; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Magnusson, Patrik K. E.; Nagel, Gabriele; Pershagen, Goran; Peters, Annette; Rizzuto, Debora; Schouw, Yvonne T. van der; Samoli, Evangelia; Sorensen, Mette; Stafoggia, Massimo; Tjonneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Raaschou-Nielsen, Ole und Hoek, Gerard (2022): Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project. In: British Journal of Cancer, Bd. 126, Nr. 10: S. 1499-1507

Abstract

BACKGROUND: The evidence linking ambient air pollution to bladder cancer is limited and mixed. METHODS: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O-3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. RESULTS: During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 mu g/m(3) for 2010 exposure and 1.06 (95% CI: 0.99-1.14) for baseline exposure. Effect estimates for NO2, BC and O-3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08;95% CI: 1.00-1.16 per 10 ng/m(3)). CONCLUSIONS: We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0007-0920
• Sprache: Englisch