Hyalocytes in proliferative vitreo-retinal diseases

Jones, Charlotte H.; Gui, Wei; Schumann, Ricarda G.; Boneva, Stefaniya K.; Lange, Clemens A. K.; Overdam, Koen A. van; Chui, Toco Y. P.; Rosen, Richard B.; Engelbert, Michael und Sebag, J. (2022): Hyalocytes in proliferative vitreo-retinal diseases. In: Expert Review of Ophthalmology, Bd. 17, Nr. 4: S. 263-280

Abstract

Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies;immunohistochemistry;and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1746-9899
• Sprache: Englisch