Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics

Arbustini, Eloisa; Behr, Elijah R.; Carrier, Lucie; Duijn, Cornelia van; Evans, Paul; Favalli, Valentina; Harst, Pim van der; Haugaa, Kristina Hermann; Jondeau, Guillaume; Kääb, Stefan; Kaski, Juan Pablo; Kavousi, Maryam; Loeys, Bart; Pantazis, Antonis; Pinto, Yigal; Schunkert, Heribert; Di Toro, Alessandro; Thum, Thomas; Urtis, Mario; Waltenberger, Johannes und Elliott, Perry (2022): Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. In: European Heart Journal, Bd. 43, Nr. 20: S. 1901-1916

Abstract

This document describes the contribution of clinical criteria to the interpretation of genetic variants using heritable Mendelian cardiomyopathies as an example. The aim is to assist cardiologists in defining the clinical contribution to a genetic diagnosis and the interpretation of molecular genetic reports. The identification of a genetic variant of unknown or uncertain significance is a limitation of genetic testing, but current guidelines for the interpretation of genetic variants include essential contributions from clinical family screening that can establish a de novo assignment of the variant or its segregation with the phenotype in the family. A partnership between clinicians and patients helps to solve major uncertainties and provides reliable and clinically actionable information.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0195-668X
• Sprache: Englisch