General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic

Koszoru, Kamilla; Hajdu, Krisztina; Brodszky, Valentin; Szabo, Akos; Borza, Julia; Bodai, Katalin; Ponyai, Gyoergyi; Szegedi, Andrea; Sardy, Miklos und Rencz, Fanni (2022): General and Skin-Specific Health-Related Quality of Life in Patients With Atopic Dermatitis Before and During the COVID-19 Pandemic. In: Dermatitis, Bd. 33, Nr. SUPPL 6: S92-S103

Abstract

Background: Few studies have investigated health-related quality of life (HRQoL) in patients with atopic dermatitis (AD) during the COVID-19 pandemic. Objectives: The objectives of this study were to compare HRQoL in adult AD patients before and during the pandemic and to assess measurement performance of 4 HRQoL measures. Methods: Between 2018 and 2021, a multicenter, cross-sectional survey was conducted, involving 218 adult AD patients. Health-related quality of life outcomes included the EQ-5D-5L, Skindex-16, Dermatology Life Quality Index (DLQI), and DLQI-Relevant (DLQI-R). Severity was measured using objective SCORing Atopic Dermatitis, Eczema Area and Severity Index, and Investigator Global Assessment. Results: The mean +/- SD EQ-5D-5L utility, Skindex-16, DLQI, and DLQI-R scores were 0.82 +/- 0.22, 56.84 +/- 27.46, 13.44 +/- 8.46, and 13.76 +/- 8.60, respectively. The patients reported more problems during the pandemic (P < 0.05) regarding pain/discomfort (odds ratio [OR], 1.78), worrying (OR, 1.89), concerns about persistence/reoccurrence of disease (OR, 1.88), and social relationships (OR, 1.69). The HRQoL outcomes showed strong correlations with each other (range of r(s), §0.69§ to §0.99§). The Skindex-16, DLQI, and DLQI-R were able to discriminate between severity groups with large (eta(2) = 0.20-0.23), whereas the EQ-5D-5L with moderate effect sizes (eta(2) = 0.08-0.11). Conclusions: Atopic dermatitis patients experienced significantly more problems in some areas of HRQoL during the pandemic. The EQ-5D-5L, Skindex-16, DLQI, and DLQI-R demonstrated good convergent and known-group validity and can be suitable instruments for HRQoL assessment in clinical and research settings.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1710-3568
• Sprache: Englisch