Long-term efficacy of flluocinolone in eyes with iris-lens diaphragm disruption and PCME with medication fixed in the sclera (Mefisto)

Herold, Tina R.; Vounotrypidis, Efstathios; Liegl, Raffael; Koenig, Susanna F.; Priglinger, Siegfried G. und Wolf, Armin (2022): Long-term efficacy of flluocinolone in eyes with iris-lens diaphragm disruption and PCME with medication fixed in the sclera (Mefisto). In: Retina - the Journal of Retinal and Vitreous Diseases, Bd. 42, Nr. 7: S. 1392-1398

Abstract

Purpose: The aim of our prospective off-label, interventional clinical trial was to evaluate the efficacy and safety of the fluocinolone-loop-anchoring technique over two years in eyes with iris-lens diaphragm disruption and pseudophakic cystoid macular edema. Methods: In 10 eyes, scleral fixation of fluocinolone implant was performed. Main outcome measures were the development of best-corrected visual acuity (BCVA), central retinal thickness over 24 months, and general safety of the procedure. Results: A significant improvement to 0.57 +/- 0.38 log MAR (Snellen 20/80) (range 0-1.30) was observed (P = 0.003) at 1 month. Further improvement to 0.45 +/- 036 log MAR (Snellen 20/60) was observed until month 18 (P = 0.081). Mean central retinal thickness decreased by 22% from 601.6 +/- 235.5 mu m to 449.1 +/- 128.9 mu m at 1 month. In one patient, the implant has to be removed at Month 7 because of elevated intraocular pressure and one patient after globe rupture had a retinal redetachment at Month 4. Conclusion: In this study, we showed that the treatment of recalcitrant pseudophakic cystoid macular edema with scleral fixated fluocinolone implant in eyes with disruption of the iris-lens diaphragm provides good anatomical and functional results with a reasonable safety profile over 24 months in eyes where pseudophakic cystoid macular edema is otherwise difficult to treat and often left untreated.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0275-004X
• Sprache: Englisch