Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia

Slotman, Berend J.; Clark, Mary Ann; Ozyar, Enis; Kim, Myungsoo; Itami, Jun; Tallet, Agnes; Debus, Juergen; Pfeffer, Raphael; Gentile, PierCarlo; Hama, Yukihiro; Andratschke, Nicolaus; Riou, Olivier; Camilleri, Philip; Belka, Claus; Quivrin, Magali; Kim, BoKyong; Pedersen, Anders; Felter, Mette van Overeem; Kim, Young Il; Kim, Jin Ho; Fuss, Martin und Valentini, Vincenzo (2022): Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia. In: Radiation Oncology, Bd. 17, Nr. 1, 146

Abstract

Background Magnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic triggered beam delivery, and the availability of on-table adaptive replanning. Our objective was to describe patterns of 0.35 Tesla (T)-MRgRT utilization in Europe and Asia among early adopters of this novel technology. Methods Anonymized administrative data from all 0.35T-MRgRT treatment systems in Europe and Asia were extracted for patients who completed treatment from 2015 to 2020. Detailed treatment information was analyzed for all MR-linear accelerators (linac) and -cobalt systems. Results From 2015 through the end of 2020, there were 5796 completed treatment courses delivered in 46,389 individual fractions. 23.5% of fractions were adapted. Ultra-hypofractionated (UHfx) dose schedules (1-5 fractions) were delivered for 63.5% of courses, with 57.8% of UHfx fractions adapted on-table. The most commonly treated tumor types were prostate (23.5%), liver (14.5%), lung (12.3%), pancreas (11.2%), and breast (8.0%), with increasing compound annual growth rates (CAGRs) in numbers of courses from 2015 through 2020 (pancreas: 157.1%;prostate: 120.9%;lung: 136.0%;liver: 134.2%). Conclusions This is the first comprehensive study reporting patterns of utilization among early adopters of a 0.35T-MRgRT system in Europe and Asia. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of on-table adaptive RT have accelerated a transition to UHfx regimens. MRgRT has been predominantly used to treat tumors in the upper abdomen, pelvis and lungs, and increasingly with adaptive replanning, which is a radical departure from legacy radiotherapy practices.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch