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**Schmid, Volker J. ORCID: https://orcid.org/0000-0003-2195-8130 (2. March 2010): Spatio-Temporal Modelling of Perfusion Cardiovascular MRI. Department of Statistics: Technical Reports, No.77 [PDF, 545kB]**

## Abstract

Myocardial perfusion MRI provides valuable insight into how coronary artery and microvascular diseases affect myocardial tissue. Stenosis in a coronary vessel leads to reduced maximum blood flow (MBF), but collaterals may secure the blood supply of the myocardium but with altered tracer kinetics. To date, quantitative analysis of myocardial perfusion MRI has only been performed on a local level, largely ignoring the contextual information inherent in different myocardial segments. This paper proposes to quantify the spatial dependencies between the local kinetics via a Hierarchical Bayesian Model (HBM). In the proposed framework, all local systems are modelled simultaneously along with their dependencies, thus allowing more robust context-driven estimation of local kinetics. Detailed validation on both simulated and patient data is provided.

Item Type: | Paper |
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Form of publication: | Publisher's Version |

Keywords: | Myocardial Perfusion MRI, Bayes, Spatio-temporal modelling, P-Splines,Markov random fields |

Faculties: | Mathematics, Computer Science and Statistics > Statistics > Technical Reports Mathematics, Computer Science and Statistics > Statistics > Chairs/Working Groups > Bioimaging |

Subjects: | 500 Science > 510 Mathematics 600 Technology > 610 Medicine and health |

URN: | urn:nbn:de:bvb:19-epub-11399-3 |

Language: | English |

Item ID: | 11399 |

Date Deposited: | 03. Mar 2010, 08:55 |

Last Modified: | 04. Nov 2020, 12:52 |

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