Improvement of head and neck symptoms in patients with atopic dermatitis treated with baricitinib based on five Phase III clinical trials

Wollenberg, Andreas; Lio, Peter; Kleyn, Elise; Bissonnette, Robert; Rueda, Maria Jose; Casillas, Marta; Chen, Yun-Fei; Lu, Na; Schloebe, Andrea und Simpson, Eric (2022): Improvement of head and neck symptoms in patients with atopic dermatitis treated with baricitinib based on five Phase III clinical trials. In: European Journal of Dermatology, Bd. 32, Nr. 4: S. 522-529

Abstract

BackgroundIn adults with atopic dermatitis (AD), head and/or neck involvement is frequent, bothersome, and impacts quality of life, however, long-term topical corticosteroids (TCS) are contraindicated for this difficult-to-treat region. Baricitinib, an oral, selective, reversible inhibitor of Janus kinase 1/2 has demonstrated efficacy in adult patients with moderate-to-severe AD.ObjectivesFor this post hoc analysis, data from five Phase III trials were used to investigate the efficacy of baricitinib in patients with head and neck involvement.Materials & MethodsData were obtained from BREEZE-AD1, -AD2, -AD4, -AD5, and -AD7;Phase III, multicenter, randomized, double-blind, placebo-controlled studies conducted in patients >= 18 years with moderate-to-severe AD. BREEZE-AD1, -AD2, and -AD5 evaluated baricitinib as monotherapy, and BREEZE-AD4 and -AD7 evaluated baricitinib in combination with TCS, topical calcineurin inhibitors, or topical PDE-4 inhibitors, where available. The proportion of patients with improvement of Eczema Area and Severity Index (EASI) total score from baseline of >= 50% (EASI50) and >= 75% (EASI75), as well as head/neck EASI50 and EASI75 and erythema head/neck EASI50 and EASI75 response rates were assessed up to Week 16.ResultsAcross the studies, 93-98% of patients had head/neck involvement at baseline (EASI head/neck score >= 1). Baricitinib was similarly effective based on EASI total score for the entire body in all studies. In the monotherapy studies, the proportion of patients achieving head/neck EASI50 and EASI75 scores was significantly higher for baricitinib 2-mg and 4-mg versus placebo at Weeks 1 and 16.ConclusionBaricitinib 2-mg and 4-mg treatment showed rapid and substantial reduction in AD head and neck severity, including erythema.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1167-1122
• Sprache: Englisch